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SS-31 Peptide – Advanced Mitochondrial-Targeted Support (Elamipretide)

Elevate cellular energy and combat oxidative stress at its source with SS-31 (also known as Elamipretide, MTP-131, or Bendavia), a cutting-edge synthetic tetrapeptide engineered to selectively target and protect mitochondria — the powerhouses of your cells. By binding with high affinity to cardiolipin in the inner mitochondrial membrane, SS-31 stabilizes mitochondrial structure, optimizes electron transport chain efficiency, reduces excessive reactive oxygen species (ROS) production, and enhances ATP synthesis without interfering with healthy mitochondria.

Key Features & Benefits:

  • Mitochondrial Protection & Repair — Directly interacts with cardiolipin to prevent peroxidation, inhibit cytochrome c peroxidase activity, promote efficient electron transfer, and block mitochondrial permeability transition pore opening — helping preserve mitochondrial integrity under stress.
  • Boosted Cellular Energy — Improves oxidative phosphorylation coupling, increases ATP production, and restores bioenergetics in dysfunctional mitochondria, supporting overall vitality and endurance.
  • Powerful Antioxidant Action — Scavenges mitochondrial ROS, reduces oxidative damage, and mitigates inflammation, apoptosis, and fibrosis in preclinical models.
  • Broad Research Applications — Explored for age-related decline, muscle function, cognitive health, cardiovascular support, kidney protection, neuroprotection, and conditions involving mitochondrial dysfunction (e.g., ischemia-reperfusion injury, aging skeletal muscle, and more).
  • Convenient Administration — Typically supplied as lyophilized powder for reconstitution; administered via subcutaneous injection for rapid mitochondrial uptake and bioavailability.

Why Choose SS-31? In an era focused on longevity and cellular optimization, SS-31 stands out as a mitochondria-specific therapeutic that addresses root causes of fatigue, reduced performance, and age-related decline. Preclinical studies demonstrate rapid improvements in mitochondrial morphology, energy output, exercise capacity, and tissue resilience — making it a favorite in advanced wellness, anti-aging, and regenerative protocols. Users in research settings often report enhanced energy, better recovery, and support for metabolic health when integrated with lifestyle optimization.

Why you should trust us

Over the past two decades, Innerbody Research has helped tens of millions of readers make more informed decisions about staying healthy and living healthier lifestyles.

As a team, we’ve put in close to 2,000 hours of research and writing on the subject of therapeutic peptides, and the number continues to grow. Through our close readings of scientific studies and reviews, as well as our relationships with clinicians and patients, we’ve been able to produce comprehensive profiles of even obscure peptide therapies.

Additionally, like all health-related content on this website, this guide was thoroughly vetted by one or more members of our Medical Review Board for accuracy and will continue to be monitored for updates by our editorial team.

What is SS-31?

SS-31 is a synthetic tetrapeptide. It’s alternatively known as MTP-131 and is currently being developed by Stealth BioTherapeutics under the trademarks Elamipretide and Bendavia.

It’s specifically designed to target mitochondria. On entering the body, SS-31 binds with high affinity to cardiolipin, a phospholipid uniquely found in the inner mitochondrial membrane and known to interact with a protein called cytochrome c. This interaction determines whether cytochrome c becomes either an electron carrier or a peroxidase, and SS-31 promotes conversion to the former instead of the latter. As an electron carrier, cytochrome c drives the synthesis of adenosine triphosphate (ATP), our primary form of cellular energy. ATP production is the principal function of mitochondria, so SS-31’s presence helps ensure that the “powerhouses of the cell” continue to carry out their critical role.

SS-31 may also inhibit the opening of a channel in the inner membrane called the mitochondrial permeability transition pore (mPTP), at least in rodents. Because mPTP opening has been implicated in neuronal death, SS-31’s inhibitory action is a potential mechanism of action for the peptide’s cognitive health benefits.

Furthermore, several studies have concluded that SS-31 is capable of scavenging mitochondrial reactive oxygen species, making it a potent antioxidant. Its antioxidant mechanism of action isn’t yet fully understood, but one group of researchers has theorized that it has to do with an ability to activate autophagy — a cellular recycling process that promotes efficient function and which is critical for mitigating oxidative stress.

Current therapeutic uses of SS-31

Clinical studies on SS-31 support its use as a treatment for multiple aging-related changes, including those related to cognition, physiology, and vision. Though the lion’s share of supportive studies were conducted in animal models, they broadly paint a positive picture of the peptide’s therapeutic potential.

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