Zepbound (tirzepatide) is a prescription weight loss medicine. It contains tirzepatide, the same active ingredient as the type 2 diabetes medicine Mounjaro. The FDA approved Zepbound in 2023 to help adult people with excess weight or obesity lose weight and keep it off, especially those who also have other health conditions affected by excess weight, such as high blood pressure, type 2 diabetes, and heart disease. Zepbound is usually injected once weekly, along with eating fewer calories and being more physically active. It comes in a ready-to-use pen for home injections.
How Does Zepbound Reduce Weight?
Tirzepatide works by activating two proteins called glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) which belong to a group of hormones called incretins. Incretins are naturally produced by the intestine (gut) as soon as food enters your body and stimulate the production of insulin, a hormone that helps digest sugar.
GLP-1 also helps control your appetite by working in your brain and slows down the movement of food through your stomach. This makes you feel full faster and stay full longer after eating. As a result, you may eat less and lose weight.
Is It Right for Me?
Zepbound may be the right choice for you if:
- You have obesity.
- You have excess weight and other health problems because of it. Some examples of health problems related to excess weight are hypertension (high blood pressure), dyslipidemia (high levels of fat, including cholesterol and triglycerides, in the blood), type 2 diabetes, apnea (when breathing pauses repeatedly during sleep), and heart disease.
Your health care provider will measure your weight and height and calculate your body mass index (BMI) by dividing your weight (in kilograms) by your height (in meters) squared. If your BMI is 27 or more, you have excess weight. If your BMI is 30 or more, you have obesity. Your doctor will also examine you and review your medical history to decide if Zepbound is right for you.
How Was It Studied for Weight Loss?
Two clinical studies, SURMOUNT-1 and SURMOUNT-2, were done to see the benefits and risks of Zepbound for weight loss in adult people with excess weight. The first study, SURMOUNT-1, was done in people without diabetes, and the second, SURMOUNT-2 , was done in people with type 2 diabetes.
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